Effect of oxytocin combined with carboprost drugs on the prevention of postpartum hemorrhage after cesarean section in women with scarred uterus
Objective To explore the preventive effect of oxytocin combined with carboprost methylate suppository or carboprost tromethamine on postpartum hemorrhage in puerperae with scar uterus undergoing cesarean section.Methods 100 puerperae with scar uterus were randomly collected in the hospital as the study subjects,and were divided into control group(n=50)and experimental group(n=50)according to the simple randomization method.The control group was treated with oxytocin combined with carboprost methylate suppository therapy,and the experimental group was given oxytocin combined with carboprost tromethamine therapy.The coagulation function[activated partial thromboplastin time(APTT),plasma thrombin time(TT)and fibrinogen(Fib)]before surgery and at 2 hours after surgery,the hemorrhage volumes during surgery and at 2 hours and 24 hours after surgery,uterine contractions and the incidence rates of adverse reactions were compared between the 2 groups.Results The APTT,TT and Fib in the 2 groups at 2 hours after surgery were shorter or lower than those before surgery(P<0.05),and the above indicators in experimental group were shorter or lower than those in control group(P<0.05).The hemorrhage volumes during surgery and at 2 hours and 24 hours after surgery were less in experimental group than those in control group(P<0.05).The number of cases with good uterine contractions in experimental group was more than that in control group(P<0.05).There was no statistical differences in the incidence rates of adverse reactions between the 2 groups(P>0.05).Conclusion Both oxytocin combined with carboprost methylate suppository or carboprost tromethamine can promote uterine contractions and prevent postpartum hemorrhage in puerperae with scar uterus after repeated cesarean section,but oxytocin combined with carboprost tromethamine has a better effect,and the both methods have high safety.
NETL
NSTL
万方数据
维普
