Efficacy of pulmonary surfactant combined with caffeine citrate on neonatal respiratory distress syndrome
Objective To explore the clinical efficacy of pulmonary surfactant(PS)combined with caffeine citrate in the treatment of children with neonatal respiratory distress syndrome(NRDS).Methods 92 children with NRDS were enrolled and divided into observation group(n=46)and control group(n=46)by using the random two-color ball method.The control group was treated with caffeine citrate,and the observation group was combined with PS on the basis of the control group.The both groups were continuously treated for 7 days.The clinical indicators(mechanical ventilation time,oxygen supply time,and hospital stay)in the 2 groups were recorded,and the clinical treatment effect after 7 days of treatment and blood gas indexes[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SpO2)]and serum biochemical factors[serum ferritin(SF),C-reactive protein(CRP),procalcitonin(PCT)]before and after treatment were compared between the 2 groups.The complications were recorded in the 2 groups during treatment.Results After 7 days of treatment,the observation group had significantly shorter oxygen supply time,mechanical ventilation time and hospital stay than the control group(P<0.05).The total effective rate of clinical treatment in observation group(93.5%)was significantly higher than that in control group(78.3%),P<0.05.The PaO2 and SpO2 in the 2 groups were significantly enhanced compared with those before treatment,and the above indicators in observation group were significantly higher than those in control group(P<0.05).The PaCO2,SF,CRP and PCT in the 2 groups were significantly reduced compared with before treatment,and the indicators were significantly lower in observation group than those in control group(P<0.05).The total incidence rate of complications in observation group(13.0%)was significantly lower compared with that in control group(30.4%)(P<0.05).Conclusion PS combined with caffeine citrate can effectively enhance the clinical treatment effect of NRDS,improve the blood gas indexes,and promote the recovery of pulmonary function,and it has low risk of complications during treatment and good safety.
pulmonary surfactantcaffeine citrateneonatal respiratory distress syndromeblood gas indexesclinical efficacycomplications
NETL
NSTL
万方数据
维普
