首页|五灵胶囊治疗非酒精性脂肪性肝病的效果

五灵胶囊治疗非酒精性脂肪性肝病的效果

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目的 探究五灵胶囊治疗非酒精性脂肪性肝病的效果。方法 选取2021年3月—2023年3月3家医疗机构收治的269例非酒精性脂肪性肝病患者作为研究对象,其中29例未入组,纳入病例240例。用随机数字表法分为对照组和试验组,每组120例。对照组予以多烯磷脂酰胆碱胶囊治疗,试验组予以五灵胶囊治疗。比较2组患者的症状改善情况、血脂指标、肝功能指标及不良反应发生情况。结果 治疗后,试验组右肋胀痛、周身困重、腹胀嗳气、倦怠无力评分均低于对照组(P<0。05);试验组总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白(low-density lipoprotein cholesterol,LDL-C)水平均低于对照组;试验组治疗后的受控衰减参数(controlled attenuation parameter,CAP)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆红素(total bilirubin,TBiL)水平均低于对照组(P<0。05);2组不良反应发生率比较,差异无统计学意义(P>0。05)。结论 用五灵胶囊治疗非酒精性脂肪性肝病可有效缓解患者的临床症状,改善其血脂与肝功能,且安全性好。
Effect of Wuling Capsules in the treatment of non-alcoholic fatty liver disease
Objective To investigate the efficacy of Wuling Capsules in the treatment of non-alcoholic fatty liver disease(NAFLD).Methods From March 2021 to March 2023,a total of 269 cases of NAFLD(29 cases shedded and 240 cases were effective)were observed in 3 medical institutions.The effective cases were divided into control group and observation group according to the random number table method.The control group received Polyene Phosphatidylcholine Capsules(n=120)and the observation group received Wuling Capsules(n=120).The symptom improvement,lipid levels,liver function index,and the occurrence of adverse effects between the 2 groups were compared.Results After treatment,the scores of right rib distension and the pain heavy body trapped,abdominal distension,and weakness were significantly lower(P<0.05);the total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),controlled attenuation parameter(CAP),alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBiL)were also significantly improved(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion The use of Wuling Capsuless in treating NAFLD can effectively alleviate the clinical symptoms in patients by improving their blood lipid levels and liver function with good safety.

Wuling Capsulesnonalcoholic fatty liver diseaseliver functionsefaty

郭寿南、郭卉、陆忠华、严桐

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无锡市第五人民医院公共卫生科,无锡 214000

天津中医药大学第一附属医院肝胆科,天津 300381

无锡市第五人民医院肝病科,无锡 214000

常州市第三人民医院中西医结合肝病科,常州 213000

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五灵胶囊 非酒精性脂肪性肝 肝功能 安全性

无锡市卫健委创新团队项目

CXTD2021009

2024

西北药学杂志
西安交通大学,陕西省药学会

西北药学杂志

CSTPCD
影响因子:0.912
ISSN:1004-2407
年,卷(期):2024.39(3)
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