Efficacy of amoxicillin-clavulanate potassium sequential therapy on children with recurrent lower respiratory tract infection
Objective To observe the efficacy of amoxicillin-clavulanate potassium sequential therapy on recurrent lower respiratory tract infection(RLRTI)in children and the influence on tidal pulmonary function and serum levels of interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-10(IL-10).Methods 92 children with RLRTI were enrolled as the research subjects,and were divided into observation group and control group by random number table method,with 46 cases in each group.The above patients were treated with amoxicillin-clavulanate potassium,and the control group was given intravenous infusion for 7 to 10 days,and the observation group was given sequential therapy regimen(intravenous infusion for 3 to 5 days,and oral administration of suspension for 4 to 5 days).The clinical efficacy,disappearance times of main symptoms(fever,cough,wheezing and pulmonary rales),recovery time of white blood cell count(WBC),hospital stay,tidal pulmonary function(tidal volume,respiratory rate,inspiratory time,expiratory time,inspiratory-expiratory ratio,peak-to-peak time ratio and peak-to-peak volume ratio),the levels of serum inflammatory factors(IL-6,IL-8 and IL-10)before and after treatment and the occurrence of adverse reactions during treatment were compared between the 2 groups.Results The total effective rate of treatment in observation group was higher than that in control group(P<0.05).The disappearance times of fever,cough,wheezing and pulmonary rales,WBC recovery time and hospital stay in observation group were shorter than those in control group(P<0.05).The respiratory frequency of the 2 groups was decreased compared with that before treatment(P<0.05)while the inspiratory time,expiratory time,peak-to-peak time ratio and peak-to-peak volume ratio were increased compared with those before treatment(P<0.05),and the peak-to-peak time ratio and peak-to-peak volume ratio in observation group were higher than those in control group(P<0.05).The levels of serum IL-6 and IL-8 in both groups were reduced compared with before treatment(P<0.05),and the levels in observation group were lower than those in control group(P<0.05).The IL-10 level was enhanced compared with that before treatment(P<0.05),and the level in observation group was higher than that in control group(P<0.05).There was no statistical difference in the incidence rate of adverse reactions between the 2 groups during treatment(P>0.05).Conclusion Amoxicillin-clavulanate potassium sequential therapy for children with RLRTI can promote the symptom recovery,improve the tidal pulmonary function and enhance the efficacy,and its mechanism may be related to the regulations of expressions of IL-6,IL-8,IL-10 and other inflammatory factors.
NETL
NSTL
万方数据
维普
