Anesthetic effect of different induction doses of midazolam in radical thyroidectomy
Objective To study the anesthetic effect of different induction doses of midazolam in radical thyroidectomy and its effect on the quality of awakening.Methods A total of 160 patients undergoing radical thyroidectomy were randomly divided into group A,group B1,group B2 and group B3,with 40 patients in each group.During anesthesia induction,group A did not use midazolam,while group B1,group B2 and group B3 received intravenous injection of 0.05,0.10 and 0.15 mg·kg-1 midazolam respectively.The hemodynamic indexes mean arterial pressure(MAP),blood oxygen saturation(SpO2)and heart rate(HR),awakening indexes,visual analogue score(VAS),Richmond agitation-sedation scale(RASS)and mini-mental state examination(MMSE)were compared among the 4 groups.Results The t1(after anesthesia induction),t2(operation end),MAP and HR in B1,B2 and B3 groups were higher than those in group A,while the t2 MAP and HR in group B2 were higher than those in group B1 and B3.The t2 SpO2 in group B1,B2 and B3 was lower than that in group A,and t2 SpO2 in group B2 was lower than that in group B1 and B3(P<0.05).On the third day after operation,the VAS scores of group B1,group B2 and group B3 were lower than those of group A(P<0.05),and the VAS scores of group B2 were lower than those of group B1 and group B3(P<0.05).The incidence of restlessness in group B1,B2 and B3 was significantly lower than that in group A(P<0.05),and that in group B2 and B3 was lower than that in group B1(P<0.05).The awakening time of group B1,B2 and B3 was earlier than that of group A,and that of group B2 was earlier than that of group B1 and B3(P<0.05).The t2,t3(postoperative end 12 hours),t4(postoperative end 24 hours)RASS scores of group B1,group B2 and group B3 were significantly lower than those of group A(P<0.05),while those of group B2 were lower than those of group B1 and group B3(P<0.05).The postoperative 3-day MMSE scores of group B1,group B2 and group B3 were lower than those of group A(P<0.05),while those of group B2 were higher than those of group B1 and group B3(P<0.05).Conclusion Using 0.10 mg·kg-1 midazolam during anesthesia induction in radical thyroidectomy for thyroid cancer has good sedative effect,low degree of pain and good quality of awakening,which is worthy of clinical promotion.
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万方数据
维普
