Evaluation of different antibiotic use strategies for preterm infants with gestational age less than 32 weeks
Objective To study the clinical efficacy of different antibiotic use strategies on preterm infants with gestational age less than 32 weeks and their effects on clinical outcomes.Methods 180 premature infants with gestational age less than 32 weeks(treated with antibiotic use strategy improvement)were selected as the strategy improvement group,and 180 premature infants with gestational age less than 32 weeks(treated with empirical antibiotics)were selected as the empirical treatment group.Both groups were observed until premature infants were discharged or died.The use of antibiotics,the main intestinal flora of early feces,the incidence of nosocomial infection and clinical outcomes during the observation period were compared between the 2 groups.Results ①Early antibiotic use time:the proportion of≤3 days and 4-7 days in the strategy improvement group was higher than that in the empirical treatment group,and the proportion of>7 days was lower than that in the empirical treatment group(P<0.05).②Duration of antibiotic use during hospitalization:the strategy improvement group was shorter than the empirical treatment group,P<0.05;③Antibiotic use rate during hospitalization:the strategy improvement group was lower than the empirical treatment group,P<0.05.④Proportions of early fecal Bacillus,Lactococcus and Enterococcus:at 3,5 and 7 days after birth,the 2 groups showed a decreasing trend,and the strategy improvement group was more obvious(P<0.05).⑤During the observation period,the incidence of total infection and total adverse outcomes in the strategy improvement group(5.00%,10.00%)were lower than those in the empirical treatment group(11.11%,23.89%),P<0.05.Conclusion The improved treatment of antibiotic use strategy in premature infants with gestational age less than 32 weeks can effectively improve the use of antibiotics in premature infants,alleviate the disorder of main intestinal flora in early feces,reduce the incidence of nosocomial infection,and improve the clinical outcome,which has a good therapeutic effect.
NETL
NSTL
万方数据
维普
