Effect of esmolol on improving cardiac function in patients with subarachnoid hemorrhage
Objective To analyze the effect and safety of esmolol on cardiac function in patients with subarachnoid hemorrhage(SAH).Methods 98 patients with SAH were retrospectively selected and interventional embolization was performed.According to the treatment methods,the patients were divided into 2 groups.Group A(50 cases)was given esmolol and group B(48 cases)was given metoprolol.The cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)],myocardial injury indexes[cardiac troponin Ⅰ(cTnⅠ),brain natriuretic peptide(BNP)],catecholamine levels[norepinephrine(NE),dopamine(DA)],inflammatory factor levels[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before the operation,1,3,and 7 days after the operation in both groups were compared,and the incidence of adverse reactions of the 2 groups was counted.Results The levels of LVESD,LVEF,LVEDD,cTnⅠ,BNP,NE,DA,IL-6,and TNF-α in group A were better than those in group B,1,3 and 7 days after the operation(P＜0.05).The incidence of adverse reactions in group A was 10.42%,and that in group B was 6.00%.There was no statistically significant difference in safety between the 2 groups(P＞0.05).Conclusion Esmolol in SAH treatment can improve cardiac function,reduce myocardial injury,and reduce the levels of catecholamines and inflammatory factors.with high safety.
万方数据
维普
