Efficacy of rivaroxaban and warfarin in elderly patients with non-valvular atrial fibrillation complicated with renal insufficiency
Objective To investigate the efficacy of rivaroxaban and warfarin in the treatment of elderly patients with nonvalvular atrial fibrillation complicated with renal insufficiency.Methods 120 elderly patients with non-valvular fibrillation complicated with renal insufficiency were selected as the research object,and were divided into control group and research group according to their willingness to take drugs,with 60 cases in each group.The control group was treated with warfarin,while the study group was treated with rivaroxaban.The therapeutic effects of the 2 groups were counted,and the coagulation indexes[fibrinogen(FIB),thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),international normalized ratio(INR)],platelet index[P-selection(PS),mean platelet volume(MPV),platelet activating factor(PAF)]and N-terminal pro-B-type natriuretic peptide(NT-probnp),the occurrence of thromboembolic events and bleeding events were compared between the 2 groups.Results The total effective rate of the study group(91.67%)was higher than that of the control group(76.67%),P＜0.05.After treatment,the PT and APTT were prolonged and INR was increased in the control group(P＜0.05).The TT,PT and APTT in the study group were all prolonged(P＜0.05),and TT and APTT in the study group were all prolonged,and INR was lower than that in the control group(P＜0.05).The levels of serum PS,MPV,PAF and NT-proBNP in the study group were lowered than those in the control group(P＜0.05).The incidence of bleeding in the study group was lower than that in the control group(P＜0.05).Conclusion Rivaroxaban is more effective in the treatment of elderly patients with nonvalvular atrial fibrillation complicated with renal insufficiency,and it is more ideal than warfarin in improving coagulation function and controlling the risk of bleeding events.
rivaroxabanwarfarinnon-valvular fibrillationrenal insufficiencyelderlycoagulation function
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