Efficacy of vitamin C assisted azithromycin sequential therapy in children with Mycoplasma pneumoniae pneumonia
Objective To investigate the clinical effect of vitamin C assisted azithromycin sequential therapy in the treatment of children with Mycoplasma pneumoniae pneumonia(MPP),and to analyze the influence on serum immunoglobulins and CD4+/CD8+ratio.Methods A total of 120 children with MPP were randomly divided into observation group and control group,with 60 cases in each.The control group received azithromycin sequential therapy,while the observation group received vitamin C assisted azithromycin sequential therapy.The clinical effect and changes in pulmonary function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and peak expiratory flow(PEF)],serum immunoglobulins[immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)]and lymphocyte subsets(CD3+,CD4+and CD4+/CD8+)before and after treatment were compared between the groups.Results The total treatment response rate in the observation group(91.67%)was higher than that in the control group(78.33%),P＜0.05.After treatment,the FEV1,FVC,PEF,serum IgA,IgG and IgM levels,and the levels of CD3+,CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P＜0.05).Conclusion Vitamin C assisted azithromycin sequential therapy can improve the clinical effect of treatment and significantly improve the pulmonary function and immune function in children with MPP.
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