Effect of low-dose aspirin in high risk pregnant women with early onset preeclampsia
Objective To investigate the effect of low-dose aspirin on coagulation indexes and pregnancy outcomes in preeclampsia(PE)patients with early onset.Methods 146 PE patients with early onset were selected and randomly divided into control group and observation group,with 73 cases in each group.The control group was given general treatment,while the observation group received low-dose aspirin treatment(50 mg each time,once a day)on this basis.The pregnancy outcomes of the 2 groups were compared,and the changes of blood pressure and blood coagulation in the 2 groups before and after treatment were compared.Results After treatment,the diastolic blood pressure(DBP),systolic blood pressure(SBP)and fibrinogen(FIB)in the 2 groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group(P＜0.05);the prothrombin time(PT),thrombin time(TT)and activated partial thrombin time(APTT)in the 2 groups were significantly prolonged compared with those before treatment.Compared with the control group,the PT,TT and APTT in the observation group was significantly higher(P＜0.05).Compared with the control group,the maternal and infant adverse outcomes in the observation group were not significantly different(P＞0.05),but the adverse outcome score of the observation group showed a significant decrease compared with the control group(P＜0.05).The incidence of adverse reactions in the observation group and the control group was similar(5.48%vs.2.74%),P＞0.05.Conclusion Low-dose aspirin is safe and feasible in the treatment of patients with early onset,which can improve blood pressure control and coagulation indexes,but the effect of improving pregnancy outcomes need further study.
万方数据
维普
