Effect of Methyl Carboprost Suppositories combined with oxytocin on the prevention of postpartum hemorrhage in puerperae with scarred uterus undergoing vaginal delivery
Objective To explore the effect of different administration time of Methyl Carboprost Suppositories combined with oxytocin on preventing postpartum hemorrhage in puerperae with scarred uterus undergoing vaginal delivery.Methods 126 puerperae with scarred uterus undergoing vaginal delivery were enrolled and divided into observation group and control group by simple randomized grouping method,with 63 cases in each group.The both groups were given oxytocin during delivery.The observation group was given Methyl Carboprost Suppositories before delivery,while the control group was treated with Methyl Carboprost Suppositories after delivery.The changes in coagulation function[D-dimer(D-D),prothrombin time(PT),fibrinogen(FIB),platelet count(PLT)]before delivery and after 2 hours of delivery were compared between the 2 groups,and the differences in blood loss 1,2 and 24 hours after delivery in the 2 groups were recorded.The clinical indicators(the descending speed of uterine fundus,the duration of uterine contraction,and the duration of lochia)were compared between the 2 groups after delivery,and the occurrence of adverse drug reactions were recorded in both groups on the 3rd after delivery.Results 2 hours after delivery,the D-D,PT and PLT were significantly decreased or shortened in both groups,and the D-D and PLT in observation group were lower than those in control group,while the FIB and descending speed of uterine fundus were significantly higher than those in control group(P＜0.05).The postpartum blood loss volumes in observation group 1,2 and 24 hours after delivery were significantly less than those in control group(P＜0.05).The duration of uterine contraction in observation group was longer than that in control group,while the duration of lochia was shorter than that in control group(P＜0.05).There was no statistical difference in adverse drug reactions between the 2 groups after 3 days of delivery(P＞0.05).Conclusion Methyl Carboprost Suppositories combined with oxytocin has a good hemostatic effect in puerperae with scarred uterus undergoing vaginal delivery,and it can effectively reduce the occurrence of postpartum hemorrhage,and the efficacy of medication before delivery is better than that after delivery.
万方数据
维普
