Efficacy of betahistine combined with anisodamine hydrobromide in the treatment of vertigo
Objective To study the efficacy and safety of betahistine combined with anisodamine hydrobromide in the treatment of patients with vertigo and influence on hemodynamics,serum platelet activating factor(PAF)and thromboxane B2(TXB2).Methods 80 patients with vertigo were divided into betahistine group and control group according to random number table method,with 40 cases in each group.The control group was treated with anisodamine hydrobromide,and the betahistine group was additionally given betahistine on the basis of the control group.The both groups were treated for 14 days.After treatment,the vertigo degree was assessed by vertigo symptom score-short form(VSS-SF)and vertigo dizziness handicap inventory(DHI).Transcranial doppler(TCD)was used to evaluate the blood flow status of the left vertebral artery,right vertebral artery and vertebrobasilar artery.The levels of serum PAF and TXB2 were determined in both groups.The total effective rate after treatment was counted and the adverse reactions(vomiting,allergic reaction,sleep disorder,abnormal liver function,or abnormal coagulation function)were observed in the 2 groups.Results The total effective rate in betahistine group after treatment was higher compared with that in control group(P＜0.05).After treatment,the scores of VSS-SF and DHI in betahistine group were lower than those in control group(P＜0.05),and the blood flow status of left vertebral artery,right vertebral artery and vertebrobasilar artery were better than those in control group(P＜0.05),and the levels of PAF and TXB2 were lower when compared with control group(P＜0.05).There was no statistically significant difference in the incidence rates of adverse reactions between the 2 groups.Conclusion Betahistine combined with anisodamine hydrobromide has a good clinical effect in the treatment of vertigo.The combination can improve the vertigo symptom and vertigo degree,reduce the levels of inflammatory factors,and has a good improvement effect on cerebral hemodynamics.
万方数据
维普
