Application of sufentanil,remifentanil and fentanyl combined with propofol in painless gastrointestinal endoscopy
Objective To observe the application of sufentanil,remifentanil and fentanyl combined with propofol in outpatient painless gastrointestinal endoscopy.Methods A total of 240 patients who underwent painless gastrointestinal endoscopy in the outpatient department of the hospital were enrolled,and randomly divided into group F(fentanyl group),group S(sufentanil group),and group R(remifentanil group),with 80 cases in each group.All patients were injected with propofol.In addition,patients in group F,group S and group R were given intravenous injection of fentanyl,sufentanil and remifentanil,respectively.The general data,anesthesia conditions,duration of examination,and the total dosage of propofol were compared among the 3 groups.The vital signs of the 3 groups before examination,during examination,and after 5 minutes of examination were recorded.The incidence rates of adverse reactions in the 3 groups during and after anesthesia were recorded.Results The general data,analgesic and sedative effects of the 3 groups were similar(P＞0.05).The onset time and awakening time of group S and group R were shorter than those of group F.The onset time,awakening time and waking time of group R were shorter than those of group F(P＜0.05).There was no significant difference in waking time between group F and group S(P＞0.05).The operation time of the 3 groups was similar.The total dosages of propofol in group S and group R were lower than that in group F(P＜0.05),and the total dosage of propofol in group R was lower than that in group S(P＜0.05).The heart rate(HR),mean arterial pressure(MAP)and oxygen saturation(SpO2)in the 3 groups during examination were lower than those before examination(P＜0.05).The 3 indicators after 5 minutes of examination were higher than those during examination(P＜0.05),but there was no significant difference before examination and after 5 minutes of examination(P＞0.05).The MAP and SpO2 in group R during examination were lower than those in group F and group S.There was no statistically significant difference in HR,MAP or SpO2 between group F and group S(P＞0.05).The incidence rates of adverse reactions during and after anesthesia showed no statistically significant difference among the 3 groups(P＞0.05).Conclusion The 3 adminiatration regimes are safe in painless gastrointestinal endoscopy.The onset time,awakening time,waking time and total dosage of propofol of anesthesia with remifentanil combined with propofol are shorter/lower than those of sufentanil or fentanyl combined with propofol.Anesthesia with remifentanil combined with propofol results in the most obvious respiratory depression.
万方数据
维普
