Analysis of sedative effect of dexmedetomidine in CT examination of children
Objective To compare the effect of different sedation methods in CT examination of children.Methods Sixty children patients were enrolled and randomly divided into group D(chloral hydrate 0.5 mL·kg-1 enema combined with dexmedetomidine 1.5 μg·kg-1 nasal drip)and group M(chloral hydrate 0.5 mL·kg-1 enema combined with midazolam 0.05 mg·kg-1 intravenous injection),with 30 cases in each group.The hemodynamic indicators,sedation satisfaction,Ramsay sedation scale(RSS)score,sedation onset time,sedation recovery time and adverse reactions were observed.Results Compared with the baseline,the RSS scores of children at 10,20 and 30 minutes after administration were statistically significant(P＜0.05),and the RSS scores and sedation effect in group D on CT table were better than those in group M.There were significant differences in sedation onset time,recovery time and total examination time between the 2 groups(P＜0.05),and all of them were shorter in group D.There were significant differences in some hemodynamic parameters such as the mean heart rate and blood pressure between the 2 groups(P＜0.05).During medication,no adverse event was observed in the 2 groups.Conclusion Compared with chloral hydrate 0.5 mL·kg-1enema combined with midazolam 0.05 mg·kg-1 intravenous injection,chloral hydrate 0.5 mL·kg-1 enema combined with dexmedetomidine 1.5 μg·kg-1 nasal drip has more advantages in children CT examination,such as more stable hemodynamics,more satisfactory sedation effect and shorter recovery time.
万方数据
维普
