Investigation on the factors of Acinetobacter baumannii infection in Xingtai People's Hospital
Objective To analyze the distribution and drug resistance characteristics of Acinetobacter baumannii(AB)infection and risk factors for multi-drug resistant(MDR)bacteria infection in Xingtai People's Hospital.Methods The clinical data of 126 patients with AB infection were collected retrospectively.The distribution and drug resistance characteristics of AB infection were analyzed.According to the presence or absence of MDR-AB,the patients were divided into MDR-AB group and non-MDR-AB group.The risk factors of MDR-AB infection were analyzed,and a prediction model for MDR-AB infection was constructed.Results The 126 patients infected with AB were from the intensive care unit(ICU)(34.13%),department of respiratory medicine(25.40%)and department of craniocerebral surgery(20.63%).The main infection sites included bloodstream(28.57%),central nervous system(26.19%)and urinary system(26.19%).66.67%of the patients developed MDR-AB infection,and 123 MDR-AB strains were detected.The resistance rates of pathogenic bacteria of AB infection to meropenem,imipenem,ciprofloxacin,cefepime,ceftazidime and ceftriaxone were higher than 95.00%.The resistance rates to levofloxacin,aztreonam,ampicillin-sulbactam and piperacillin-tazobactam were higher than 70%.The resistance rates to minocycline and tigecycline were low.The proportions of patients≥60 years old,hospital stay≥12 days,invasive procedures,APACHE Ⅱ score at admission≥20,and combined use of antibiotics in MDR-AB group were significantly higher than those in non-MDR-AB group(P＜0.05).The age,length of hospitalization,invasive procedures,APACHE Ⅱ score at admission and combined use of antibiotics were risk factors of MDR-AB infection(P＜0.05).The area under the curve(AUC),sensitivity and specificity of the prediction model constructed based on these risk factors to predict MDR-AB infection were 0.895,79.52%and 89.94%,respectively.Conclusion Hospital AB infection mostly occurs in ICU,and lower respiratory tract infection is the most common.The pathogenic bacteria are sensitive to minocycline and tigecycline.The prediction model constructed based on risk factors of MDR-AB infection is helpful for prediction.
万方数据
维普
