首页|鲜品药材治疗不稳定型心绞痛的效果及对细胞因子水平的影响

鲜品药材治疗不稳定型心绞痛的效果及对细胞因子水平的影响

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目的 探讨服用鲜品药材与服用饮片药材对气虚血瘀型不稳定型心绞痛(unstable angina pectoris，UAP)的效果差异。方法 选择不稳定型心绞痛患者，随机分成对照组、饮片组和鲜药组，每组36例，维持现有的西医治疗方式不变，对照组不给中药治疗，饮片组用桃红四物汤、四妙勇安汤加减治疗，鲜药组将地黄和金银花替换为鲜药进行治疗，疗程为4周，比较各组心绞痛发作次数、心绞痛发作持续时间、硝酸甘油消耗量，炎性因子白细胞介素-6(interleukin-6，IL-6)和肿瘤坏死因子-α(tumor necrosis factor alpha，TNF-α)，血脂指标和中医证候积分的变化。结果 鲜药组心绞痛发作次数、持续时间和硝酸甘油用量，以及TNF-α、IL-6水平明显优于饮片组(P<0。05);在中医证候积分方面，鲜药组较饮片组下降得更为显著(P<0。05);血脂指标方面，鲜药组和饮片组仅胆固醇(cholesterol，TC)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol，LDL-C)有所下降;饮片组治疗4周的总有效率为76。5%，鲜药组为80。0%，2组比较差异无统计学意义(P>0。05)，鲜药组的显效率为48。6%，明显高于饮片组的17。6%(P<0。05)。结论 中药能显著改善UAP患者心绞痛发作情况，调整部分饮片为鲜药后，临床效果更佳。
Effect of fresh herbs on unstable angina pectoris and influence on cytokine levels
Objective To investigate the differences of therapeutic effect between the fresh herbs and Chinese decoction pieces in the treatment of unstable angina pectoris(UAP)of the Qi deficiency and blood stasis type.Methods Patients with UAP were randomly divided into control group,Chinese decoction pieces group and fresh herbs group,with 36 cases in each group.During the study,the existing western medical treatment was maintained in the all groups.The control group was not given Chinese medicine treatment.The Chinese decoction pieces group was treated with Taohong Siwu Decoction and Simiao Yong'an Decoction,while the fresh herbs group was treated with rehmannia and honeysuckle for 4 weeks.The number of angina pectoris,duration of angina pectoris,nitroglycerin consumption,inflammatory factors Interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α),blood lipid index and traditional Chinese medicine(TCM)syndrome score were compared.Results The number of angina pectoris,duration of angina pectoris,nitroglycerin consumption,TNF-α and IL-6 levels were significantly better in the fresh herb group than in the decoction pieces group(P<0.05).In terms of TCM symptoms,the fresh herb group showed a more significant decrease than the decoction pieces group(P<0.05).In terms of lipid indexes,only cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)decreased in the fresh herb group and the decoction pieces group.The total effective rate of 4 weeks of treatment was 76.5%in decoction pieces group and 80.0%in fresh herb group with no significant difference between the 2 groups(P>0.05),but the effective rate was 48.6%in the fresh herb group compared with 17.6%in the decoction pieces group(P<0.05).Conclusion Chinese medicine can significantly improve the angina pectoris in UAP patients and the clinical effects can be improved after adjusting some of the decoction pieces to fresh herbs.

fresh herbunstable angina pectorisQi deficiency and blood stasis

刘峰、刘星、吕炳鑫、王毅盟、李继光

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河北中石油中心医院健康管理科,廊坊 065000

鲜品药材 不稳定型心绞痛 气虚血瘀证

河北省中医药管理局中医药类科学研究课题计划项目廊坊市科技支撑计划项目

20232392022013123

2024

10.3969/j.issn.1004-2407.2024.05.021

西北药学杂志
西安交通大学,陕西省药学会

西北药学杂志

CSTPCD
影响因子：0.912
ISSN：1004-2407
年,卷(期)：2024.39(5)