Efficacy of ambroxol aerosol inhalation combined with intravenous infusion in the treatment of neonatal aspiration pneumonia
Objective To investigate the clinical efficacy of ambroxol intravenous drip combined with atomization inhalation in the treatment of neonatal aspiration pneumonia,and to observe the effects on the levels of tumor necrosis factor-α(TNF-α)and insulin-like growth factor(IGF-1).Methods A total of 80 newborn children with aspiration pneumonia were selected and divided into observation group and control group according to random number table method,40 cases in each group.The control group was treated with conventional intravenous infusion of ambroxol hydrochloride,while the observation group was treated with atomization inhalation of ambroxol hydrochloride.The both groups were treated for 7 days.The curative effect,symptom disappear time,inflammatory reaction,oxidative stress reaction and adverse drug reaction were observed.Results After treatment,the clinical effective rate of observation group was significantly higher than that of control group(P<0.05).The time fever disappearance,cough,pulmonary rales and asthma in observation group was significantly shorter than that in control group(P<0.05).The levels of TNF-α and interleukin-6(IL-6)in observation group were significantly lower than those in control group(P<0.05),and the level of IGF-1 was significantly higher than that in control group(P<0.05).The level of superoxide dismutase(SOD)in observation group was significantly higher than that in control group(P<0.05),and the level of malondialdehyde(MDA)was significantly lower than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Ambroxol intravenous drip combined with atomization inhalation is effective in the treatment of neonatal aspiration pneumonia,which can significantly improve the clinical symptoms of the children,reduce the levels of inflammatory factors and oxidative stress indicators,and has a certain safety.
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