Efficacy of ilaprazole and omeprazole injection on peptic ulcer bleeding
Objective To explore the efficacy of ilaprazole and omeprazole injection in the treatment of peptic ulcer bleeding.Methods 104 patients with peptic ulcer bleeding were selected as the research subjects.Following the principle of randomization,the patients were divided into observation group(n=53)and control group(n=51).The control group was given Omeprazole Injections,while the treatment group adopted Ilaprazole Injections.The differences in hemostasis rate within 3 days of treatment,re-bleeding rate within 7 days of treatment,blood transfusion rate and hospital stay were compared between the 2 groups.The differences in the levels of serum inflammatory factor interleukin-6(IL-6),stress response indicator procalcitonin(PCT),growth factors[epidermal growth factor(EGF),and basic fibroblast growth factor(BFGF)]and coagulation function[plasma prothrombin time(PT)and activated partial thromboplastin time(APTT)]of the 2 groups were evaluated before treatment and after 3 days of treatment.The differences in adverse reactions were analyzed in the 2 groups during treatment.Results There was no statistical difference in the hemostasis rate within 3 days of treatment,re-bleeding rate within 7 days of treatment,blood transfusion rate and hospital stay between the 2 groups.After 3 days of treatment,the serum IL-6 and PCT,PT and APTT in both groups were reduced or shortened compared with those before treatment,and the above indicators in observation group were lower or shorter than those in control group during the same period(P<0.05).The EGF and BFGF levels in both groups were enhanced compared with those before treatment,and the levels in observation group were higher than those in control group(P<0.05).There was no statistically significant difference in the incidence rates of adverse reactions between the 2 groups(P>0.05).Conclusion Both ilaprazole and omeprazole have similar hemostatic effects on peptic ulcer bleeding,but ilaprazole can effectively relieve the inflammatory response and stress response and promote the ulcer repair,with good safety.
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