Effect of Levothyroxine Sodium Tablets in pregnant patients with subclinical hypothyroidism
Objective To investigate the effect of Levothyroxine Sodium Tablets on thyroid function and clinical pregnancy outcome in pregnant patients with subclinical hypothyroidism.Methods A total of 198 pregnant women with subclinical hypothyroidism were divided into control group and observation group randomly.The pregnant women in the control group were given dietary guidance,guaranteed iodine intake and avoided contact with radioactive substances.The pregnant women in the treatment group were orally treated with levothyroxine sodium.Fasting venous blood was collected in the morning before treatment and on the 1st day before delivery,and serum thyrotropin(TSH),free triiodothyronine(FT3),free tetriodothyronine(FT4)and thyroid peroxidase antibody(TPOAb)were detected by immunoluminescence method.The clinical pregnancy outcomes and postpartum complications of both groups were compared.Results After treatment,the level of TSH and TPOAb in serum of observation group was significantly lower than that in control group(P<0.05),the level of FT3 and FT4 was significantly higher than that of control group(P<0.05).The incidence of abortion,stillbirth,premature delivery,low birth weight and neonatal asphyxia in observation group had a downward trend compared with that in control group(P>0.05),and the total incidence was significantly lower than that of the control group(P<0.05).The incidence of postpartum hemorrhage,hypertension,abnormal glucose metabolism and postpartum anemia in the observation group had a downward trend compared with that in the control group(P>0.05),and the total incidence was significantly lower than that of the control group(P<0.05).Conclusion Levothyroxine Sodium Tablets can improve the thyroid function of pregnant patients with subclinical hypothyroidism and reduce the incidence of adverse pregnancy outcomes and postpartum complications.
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