目的 探讨度拉糖肽联合运动疗法对肥胖2型糖尿病(type 2 diabetes mellitus，T2DM)患者糖脂代谢及胰岛素功能的影响。方法 选取100例T2DM患者，用随机数字表法分为研究组和对照组，每组50例。对照组用度拉糖肽治疗，研究组在对照组治疗的基础上联合使用运动疗法。比较2组的糖脂代谢水平、胰岛功能指标及临床疗效。结果 治疗8周后，2组空腹血糖(fasting plasma glucos，FPG)、餐后2 h血糖(2-hours post prandial glucos，2 hPG)、糖化血红蛋白(glycosylated hemoglobin，HbA1c)、胰岛素抵抗指数(homeostatic model assessment of insulin resistan，HOMA-IR)、总胆固醇(total cholesterol，TC)和三酰甘油(triglyceride，TG)较治疗前均降低(P<0。05);研究组的FPG、2 hPG、HbA1c、TC、TG和HOMA-IR较对照组更低(P<0。05);2组的胰岛β细胞功能指数(homeostasis model assessment of β-cell insulin secretion，HOMA-β)较治疗前均升高，且研究组更高(P<0。05);研究组的治疗总有效率高于对照组(P<0。05)。结论 度拉糖肽联合运动疗法能有效控制肥胖T2DM患者的血糖，降低患者的血脂水平，促进糖脂代谢，改善胰岛功能，疗效较好。
Effects of dulaglutide combined with exercise therapy on glucose and lipid metabolism and insulin function in obese patients with type 2 diabetes mellitus
Objective To investigate the effect of dulaglutide combined with exercise therapy on glucose and lipid metabolism and insulin function in obese patients with type 2 diabetes mellitus(T2DM).Methods A total of 100 T2DM patients admitted to the hospital and randomly divided into study group(n=50)and control group(n=50).The control group was treated with dulaglutide.The study group was treated with exercise therapy on the basis of the control group.The glucose and lipid metabolism levels,islets function index levels and clinical efficacy were compared between the 2 groups.Results After 8 weeks of treatment,the levels of fasting plasma glucose(FPG),2-hours plasma glucose(2 hPG),glycosylated hemoglobin(HbA1c),homeostasis model assessment for insulin resistan(HOMA-IR),total cholesterol(TC)and triglycerides(TG)in the 2 groups were all lower than those before treatment(P<0.05).The levels of FPG,2 hPG,HbA1c,TC,TG,and HOMA-IR in the study group were lower than those in the control group(P<0.05).The levels of homeostasis model assessment of β-cell insulin secretion(HOMA-β)in both groups were higher than those before treatment,and the level of HOMA-β in the study group was higher than that in the control group(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Conclusion Dulaglutide combined with exercise therapy can effectively control blood sugar in obese patients with T2DM,reduce blood lipid levels,promote glucose and lipid metabolism,and improve islets function,with good curative effect.
dulaglutideexercise therapytype 2 diabetesobesityglycolipid metabolismislet function
万方数据
维普
