Effect of insulin pump or intravenous drip of insulin combined with intravenous rehydration on diabetic ketoacidosis
Objective To analyze the effect of insulin pump,insulin intravenous drip combined with intravenous fluid rehydration in the treatment of diabetic ketoacidosis.Methods 80 patients with diabetic ketoacidosis treated in our hospital were divided into control group and study group according to random number table method,40 cases in each group.The control group received continuous intravenous infusion of low-dose insulin combined with intravenous rehydration therapy,while the study group received subcutaneous insulin pump infusion combined with intravenous rehydration therapy.The time to negative blood ketone bodies,the time to reach the blood glucose standard,the time to negative urine ketone bodies,and the recovery time of plasma pH were compared.The insulin dosage,the incidence of hypoglycemia,the oxidative stress indexes and inflammatory response indexes[superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-PX),tumor necrosis factor alpha(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)],and the clinical efficacy of the 2 groups before and after treatment were compared.Results After treatment,compared with the control group,the time of blood ketone body turning negative,blood glucose reaching the standard time,urine ketone body turning negative time,and plasma pH recovery time in study group were significantly shorter than those in control group(P<0.05);the insulin dosage and the incidence of hypoglycemia in study group were significantly lower(P<0.05);after treatment,the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)in the 2 groups were increased,and the levels of MDA were decreased.And the levels of SOD and GSH-PX in study group were higher than those in control group,and the level of MDA was lower than that in control group(P<0.05).After treatment,the serum levels of TNF-α,CRP,and IL-6 in the 2 groups decreased,and the study group was lower than the control group(P<0.05).The total effective rate of the study group was higher than that of the control group(92.50%vs.65.00%,P<0.05).Conclusion Compared with continuous intravenous infusion of low-dose insulin,continuous subcutaneous infusion of insulin pump combined with intravenous rehydration therapy has a more significant effect,which can reduce insulin dosage,reduce the incidence of hypoglycemia,and can be used to restore blood sugar and pH value in a short time,shorten the time of blood ketone body and urine ketone body turning negative,improve the oxidative stress state of the body,and reduce the inflammatory response safely.
万方数据
维普
