Efficacy of Shugan Jieyu Anshen Decoction in the adjunctive treatment of Parkinson's disease with sleep disorder and depression
Objective To explore the efficacy of Shugan Jieyu Anshen Decoction on Parkinson's disease with sleep disorder and depression.Methods 80 patients with Parkinson's disease with sleep disorder and depression were selected as the research object,and randomly divided into control group and research group,with 40 patients in each group.The control group was treated with conventional western medicine,and the research group was treated with Shugan Jieyu Anshen Decoction on the basis of the control group.The traditional Chinese medicine symptom scores,sleep disorder[Pittsburgh sleep quality index(PSQI)],depression[Hamilton depression scale(HAMD)],neurocytokine index[brain derived neurotrophic factor(BDNF),nerve growth factor(NGF)]and neurocytokine indicators[serum 5-hydroxytryptamine(5-HT),norepinephrine(NE)]before and after treatment were compared between the 2 groups,and the clinical efficacy and adverse reactions were compared between the 2 groups.Results The main symptoms,secondary symptoms and total scores of the 2 groups after treatment were lower than those before treatment,and the research group were lower than those of the control group(P<0.05).The PSQI scores and HAMD scores of the 2 groups after treatment were lower than those before treatment,and the research group were lower than those of the control group(P<0.05).The total effective rate of the research group(95.00%)was higher than that of the control group(80.00%)(P<0.05).The levels of BDNF,NGF,5-HT and NE after treatment in the 2 groups were higher than those before treatment,and the levels in the research group were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Shugan Jieyu Anshen Decoction has a definite clinical effect on Parkinson's disease with sleep disorder and depression,and can significantly relieve the clinical symptoms of traditional Chinese medicine,regulate sleep quality and depression,obviously improve the metabolism of neurocytokines and monoamine neurotransmitters,with good safety,which is worthy of promotion.
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