目的 探讨药物治疗管理(medication therapy management，MTM)服务模式对维持性血液透析便秘患者生活质量、服药依从性的影响。方法 选取符合维持性血液透析便秘条件的患者120例，采用随机数字法分为对照组和药学干预组。药学干预组由临床药师在药学门诊或透析床边为透析便秘患者提供MTM服务。主要观察指标:便秘生活质量评估表(patient assessment of constipation quality of life，PAC-QOL)评分。次要观察指标:服药依从性量表(morisky medication adherence scale，MMAS)评分和自我效能感量表(general self-efficacy scale-schwarzer，GSES)评分。结果 药学干预组PAC-QOL评分、MMAS评分和GSES评分均显著高于对照组(P<0。001)。结论 基于MTM的维持性血液透析便秘患者的服务模式可显著改善患者的生活质量，提高服药依从性，提升自我效能感。
Impact of medication therapy management on constipation in patients with maintenance hemodialysis
Objective To evaluate the influence of maintenance hemodialysis with constipation based on medication therapy management on the quality of life,medication adherence and general self-efficacy.Methods Totally 120 patients who met the criteria for constipation in maintenance hemodialysis were selected and randomly divided into a control group and a pharmaceutical intervention group by random number method.The pharmaceutical intervention group was provided with medication therapy management services by clinical pharmacists at the pharmacy outpatient clinic or beside the dialysis bed for patients.The main outcome indicator was the patient assessment of constipation quality of life(PAC-QOL)score.The secondary outcome indicators were the morisky medication adherence scale(MMAS)score,and the general self-efficacy scale(GSES)score.Results After intervention,the PAC-QOL scores,MMAS and GSES scores of intervention group was significantly better than control group(P<0.001).Conclusion The maintenance hemodialysis with constipation based on medication therapy management could significantly improve the quality of life,medication adherence and general self-efficacy of patients.
maintenance hemodialysismedication therapy managementconstipationpharmaceutical care
万方数据
维普
