Advances in structure modification and structure-activity relationship of matrine based on antitumor effect
Objective To review matrine's anti-tumor mechanism and the structure-activity connection of its derivatives in anti-tumor treatment,as well as to give more scientific support for matrine development.Methods By using keywords such as"matrine","derivative","tumor",and"pharmacological activity",the associated studies in the CNKI,Wanfang,Weipu,PubMed,and Science Direct databases were gathered and summarized.Results Matrine is a primary active component of Sophora flavescens,which has demonstrated significant pharmacological action in digestive system malignancies,respiratory system tumors,gynecological tumors,leukemia,prostate cancer,and other malignant tumors.Its anticancer action is achieved by inducing tumor cell differentiation,causing programmed cell death,reducing tumor cell invasion and metastasis,reversing tumor cell multidrug resistance,interfering with tumor cell development cycle,and decreasing tumor cell telomerase activity.The alteration of matrine focuses mostly on the parent ring locations 13,14,15,and 16.Conclusion Matrine has strong pharmacological action against several types of cancers,and structural alteration can compensate for some of matrine's weaknesses,providing more information for matrine development.
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