Objective To explore the difference of efficacy of Yeast Burra Powder combined with infliximab and Bifidobacterium Tetrad Tablets combined with infliximab in the treatment of ulcerative colitis patients.Methods 90 patients with ulcerative colitis were prospectively selected and randomly divided into groups A,group B and group C by drawing lots,with 30 cases in each group.Group A was treated with infliximab only,group B was treated with Yeast Burra Powder combined with infliximab,and group C was treated with Bifidobacterium Tetrad Tablets combined with infliximab.All of the 3 groups were treated for 8 weeks.The total effective rate,intestinal flora,inflammatory factors and intestinal mucosal barrier function of the 3 groups were compared,and the occurrence of adverse reactions during treatment was recorded.Results The total effective rates of group B(90.00%)and group C(86.67%)were higher than that of group A(63.33%)(χ2=5.963,4.356,P<0.05).After treatment,the levels of enterococcus and enterobacter in the 3 groups were decreased,while the levels of bifidobacterium and lactobacillus were increased(F=100.897,106.595,4.353,8.165,P<0.05),and the levels of enterococcus and enterobacter in group B and group C were lower than those in group A,and those in group C were lower than those in group B(P<0.05).Bifidobacterium and lactobacillus were significantly higher than those in group A,and those in group C were higher than those in group B(P<0.05).After treatment,the levels of interleukin-6(IL-6)、tumor necrosis factor-α(TNF-α)、C-reactive protein(CRP)in the 3 groups were decreased,and the levels of interleukin-10(IL-10)were increased(P<0.05).The levels of IL-6,TNF-α and CRP in groups B and C were lower than those in group A,and those in group B were lower than those in group C(P>0.05).The IL-10 level in group B was higher than that in group A and group C,and group C was higher than group A.After treatment,the levels of lactulose/mannitol(L/M),D-lactic acid(D-LA),diamine oxidase(DAO),lipopolysaccharide(LPS)in the 3 groups were decreased(P<0.05),and those in group B and group C were lower than those in group A,and those in group B were lower than those in group C(P>0.05).There was no significant difference in the adverse reaction rate among the 3 groups(P>0.05).Conclusion The total effective rate of infliximab combined with Yeast Burra Powder and Bifidobacterium Tetrad Tablets in the treatment of ulcerative colitis patients was higher than that of infliximab alone.The combination of Bifidobacterium Tetrad Tablets can significantly improve the intestinal flora of patients,and the combination of Yeast Burra Powder can regulate inflammatory factors and improve intestinal mucosal barrier function,with good safety.However,there was no difference in safety between Yeast Burra Powder and Bifidobacterium Tetrad Tablets.
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