Study on the correlation between quantitative lymph vascular space invasion and clinical characteristics and prognosis in early cervical adenocarcinoma
Objective:To explore the correlation between quantitative lymph vascular space invasion(LVSI)and clinical characteristics and prognosis in early cervical adenocarcino-ma.Methods:Patients with cervical adenocarcinoma staged Ⅰ a1 to Ⅰ b2 and Ⅱ a1 according to the FIGO staging system were collected preoperatively.Based on a quantitative LVSI assess-ment system,LVSI was classified into three different grades,and the correlation between LVSI quantification and clinical characteristics and prognosis in early cervical adenocarcinoma was analyzed.Results:There was a statistically significant difference between LVSI quantification in cervical adenocarcinoma and lymph node(LN)metastasis(OR=4.216,95％CI:1.457～2.202,P=0.008).With a median follow-up time of 79 months,the Log-Rank test showed sta-tistically significant differences in progression-free survival(PFS),distant metastasis,and over-all survival(OS)when comparing focal LVSI to diffuse LVSI,and diffuse LVSI to negative LV-SI(P＜0.05).The Cox proportional hazards model indicated that the correlation between quan-titative LVSI and PFS and OS was statistically significant(HR=2.366,95％CI:1.061～5.275,P=0.035;HR=2.489,95％CI:1.141～5.432,P=0.022).Conclusion:Diffuse LVSI is an independent risk factor for LN metastasis in early cervical adenocarcinoma and is associat-ed with distant metastasis,OS,and PFS.Focal LVSI and negative LVSI exhibit similar patterns of recurrence and metastasis.The quantitative LVSI classification system can better predict LN metastasis,distant metastasis,OS,and PFS in early cervical adenocarcinoma compared to the traditional dichotomous classification system,which is beneficial for precise guidance in clinical treatment.
万方数据
维普
