Preparation of CS/SA-doped PVA composite fibers based on microfluidic spinning technology and their drug release properties
In recent years,the field of medicine has witnessed significant advancements,leading to an increased demand for drug slow release materials.As a result,drug slow release materials have emerged as a prominent area of research in the biomedical field.This is primarily due to their distinct advantages,including enhanced drug utilization and excellent biocompatibility.Fibrous drug sustained-release materials prepared by using microfluidic spinning technology offer a safe and stable means of loading drug molecules.Fibers,serving as drug release carriers,possess several advantages,including a large surface area and excellent biocompatibility.Therefore,this paper aimed to prepare composite drug-carrying fibers with slow-release properties using coaxial microfluidic spinning technology.The fibers were composed of natural polymer carriers,namely chitosan(CS)and sodium alginate(SA),which possess excellent biocompatibility.Additionally,a polyvinyl alcohol(PVA)solution was mixed with different ratios of polyvinyl alcohol(PVA)solution to serve as the spinning solution.The present study investigated the drug release effect of two composite drug-carrying fibers,namely PVA/CS/AS(PCA)and PVA/SA/AS(PSA),using ampicillin sodium(AS)as a drug model.Additionally,the study analyzed the influence of two types of natural polymer materials and their contents on the morphology and structure of the drug-carrying fibers,as well as their mechanical properties and drug release properties.The findings indicate that both PCA and PSA drug-carrying fibers exhibit consistent formability and possess a favorable morphological structure.The drug was effectively preserved during the fiber molding process,preventing the crystallization of drug molecules,which is essential for maintaining drug efficacy and facilitating drug release.With the augmentation of polyvinyl alcohol(PVA)content,there was a gradual enhancement in the fracture strength and elongation at break of both PCA and PSA composite fibers.Moreover,the fracture strength of PCA composite fibers was found to be higher than that of PSA composite fibers,whereas the fracture elongation of PSA composite fibers was significantly greater than that of PCA composite fibers.In addition,both types of fibers exhibited a favorable slow-release effect on pharmaceutical substances,with the rate of cumulative drug release being increased proportionally to the PVA content in the spinning solution.Among the various types of fibers studied,PCA composite fibers exhibited a rapid drug release profile,with a significant amount of the drug being released within a short period of time.Specifically,when the mass ratio of PVA to CS was 5∶1,the cumulative release rate of the drug from PCA composite fibers reached 60%within 180 minutes.On the other hand,PSA composite fibers demonstrated a sustained drug release over an extended period of time,with a release duration of 58 hours.When the mass ratio of PVA to SA was 64∶1,the cumulative release rate of drug from PSA composite fibers reached 94.1%.To sum up,compared to PCA composite fibers,the release time and cumulative release rate of drugs are improved,which is suitable for the treatment of chronic diseases and achieves the purpose of long-term effective drug release.The disparity in drug release performance between the two fibers can be attributed to variations in the performance and structure of the drug carrier material itself.By utilizing two drug-carrying composite fibers and various components within the spinning liquid,it is possible to develop a system for slow drug release that can be designed to meet the needs of different drug dosing patients.This demonstrates the wide-ranging potential for the application of slow and controlled drug release.
polyvinyl alcoholchitosansodium alginatedrug-loaded fiberssustained release of the drugcoaxial microfluidic spinning
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