现代临床护理2024,Vol.23Issue(8) :34-40.DOI:10.3969/j.issn.1671-8283.2024.08.005

1例免疫检查点抑制剂相关重度胆汁淤积性混合型肝脏毒性肺癌患者的护理

Nursing care for severe cholestatic mixed hepatotoxicity associated with immune checkpoint inhibitors:a case report

刘玉 陈岁花 朱苗苗 覃惠英
现代临床护理2024,Vol.23Issue(8) :34-40.DOI:10.3969/j.issn.1671-8283.2024.08.005

1例免疫检查点抑制剂相关重度胆汁淤积性混合型肝脏毒性肺癌患者的护理

Nursing care for severe cholestatic mixed hepatotoxicity associated with immune checkpoint inhibitors:a case report

刘玉 1陈岁花 1朱苗苗 1覃惠英2
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作者信息

  • 1. 中山大学肿瘤防治中心 临床研究部,广东广州,510060
  • 2. 中山大学肿瘤防治中心 护理部,广东广州,510060
  • 折叠

摘要

总结 1 例免疫检查点抑制剂相关重度(G4 级)胆汁淤积性混合型肝脏毒性肺癌患者的护理经验.护理要点:密切观察患者肝脏生化指标与体征;早期应用糖皮质激素联合其他免疫抑制药物;舒缓皮肤不适症状;预防机会性感染;给予个体化的运动、营养、睡眠和心理护理.29d后患者肝脏毒性降至G1 级,予转换口服免疫抑制药物治疗后出院.经过 2 个月的定期随访,患者肝功能恢复良好.

Abstract

This paper summarises the nursing experiences with a lung cancer patient who suffered Grade 4 mixed hepatotoxicity characterised with cholestasis.Summarised key care measures include close observation of liver biochemical indexes,timely and safe administration of immunosuppressants,implementation of skincare procedure,prevention of opportunistic infections,individualised exercises,nutrition care,sleep care and psychological care.The patient was discharged with oral immune inhibitors after 29 days of hospitalisation when the hepatotoxicity had been improved and down to Grade 1.In the second month of follow-up,the patient had a well-recovered liver function.

关键词

免疫检查点抑制剂/免疫检查点抑制剂相关肝脏毒性/胆汁淤积/个案护理

Key words

immune checkpoint inhibitors/immune checkpoint inhibitors associated hepatotoxicity/cholestasis/case nursing

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基金项目

广东省医学科学技术基金项目(A2022020)

出版年

2024
现代临床护理
中山大学

现代临床护理

CSTPCD
影响因子:1.317
ISSN:1671-8283
参考文献量19
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