铜调节的细胞死亡相关基因与前列腺癌关系分析
Analysis of the association between copper death-related genes and prostate cancer
李伟 1程丰 1朱俊雷 1王锁刚1
作者信息
- 1. 河南中医药大学第一附属医院泌尿外科一区,河南郑州 450003
- 折叠
摘要
目的 基于美国癌症肿瘤基因图谱(the cancer genome atlas,TCGA)数据库分析铜调节的细胞死亡相关基因与前列腺癌患者预后和免疫细胞浸润的关系.方法 从TCGA数据库下载所有前列腺癌患者的基因数据,其中包括前列腺癌组织 501 例,正常组织 52 例.运用R软件提取前列腺癌患者中铜调节的细胞死亡相关基因表达矩阵,进行差异分析、多因素回归分析筛选出预后基因,对预后基因进行生存分析,同时探讨预后相关基因与免疫细胞之间的相关性.结果 甘氨酸裂解系统蛋白 H(GCSH)与前列腺癌患者的预后显著相关,同时发现其与前列腺癌患者中的树突细胞、CD8+ T 细胞、浆细胞也显著相关(P<0.05).结论 GCSH 基因在前列腺癌的发生、发展中起重要作用,有望成为前列腺癌预后的标志物.
Abstract
Objective To analyze the association between copper death-related genes and prognosis of prostate cancer and immune cell infiltration based on the cancer genome atlas(TCGA).Methods The mRNA transcriptome data of all prostate cancer patients were downloaded from TCGA,including 501 prostate cancer tissues and 52 normal tissues.The expression matrix of copper death-related genes was extracted with R software.Differential analysis and multivariate regression analysis were con-ducted to screen out the prognostic genes,which were then analyzed to explore the correlation between prognosis-related genes and immune cells.Results GCSH gene was significantly correlated with the prognosis of prostate cancer,and significantly correlated with dendritic cells,CD8+ T cells and plasma cells(P<0.05).Conclusion GCSH gene plays an important role in the occurrence and development of prostate cancer,and may become a prognostic marker of the disease.
关键词
前列腺癌/铜调节的细胞死亡/肿瘤微环境/甘氨酸裂解系统蛋白H/美国癌症肿瘤基因图谱数据库/标志物Key words
prostate cancer/copper-related cell death/tumor microenvironment/glycine cleavage system protein H/cancer genome atlas/marker引用本文复制引用
基金项目
河南省中医药科学研究专项(2021ZY2188)
出版年
2024
NETL
NSTL
维普
万方数据