Prostate cancer(PCa)is one of the most common tumors in men.In recent years,various researches on this disease and clinical applications have benefited patients.Exosome is a subclass of extracellular vesicles(EVs).Many studies have explored the mechanisms of exosome in mediating epithelial mesenchymal transformation,angiogenesis,tumor microenvironment establishment,immune escape and drug resistance acquisition in PCa,which provides a new perspective for finding new diagnostic markers.This article reviews the role of exosome in the pathogenesis of PCa and its diagnostic application.
关键词
外泌体/前列腺癌/肿瘤标志物/肿瘤耐药/肿瘤微环境/细胞间通讯/上皮-间质转化
Key words
exosome/prostate cancer/tumor markers/tumor drug resistance/tumor microenvironment/cell to cell commu-nication/epithelial mesenchymal transformation
维普
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