Objective A two-sample Mendelian randomization method was used to explore whether there is a causal relationship between the intake of alcohol,coffee,green tea and dairy products and the incidence of prostate cancer(PCa),in order to clarify the risk factors for the incidence of PCa and find a prevention pathway for PCa.Methods Data of alcohol,coffee,green tea,dairy products and prostate cancer were collected with genome-wide association study(GWAS).The causal relationship between their intake and the risk of PCa was analyzed with two-sample Mendelian randomization(2SMR).MR analysis was conducted with inverse-variance weighting(IVW).Sensitivity analysis was performed with weighted median,MR-Egger regression,Mendelian randomization pleiotropy residual sum and outlier(MR-PRESSO)tests.Results Coffee intake(OR:0.994,95％CI:0.990-0.999,P=0.014)and green tea intake(OR:0.999,95％CI:0.998-0.999,P=0.036)were negatively correlated with the risk of PCa.Alcohol intake(OR:0.997,95％CI:0.990-1.004,P=0.392)and dairy intake(OR:1.025,95％CI:0.983-1.069,P=0.256)were not associated with the risk of PCa.In weighted median,MR-Egger regression,and retention one method analyses,the results were robust without heterogeneity or pleiotropy.Conclusion There was a causal association between coffee intake and green tea intake and the onset of PCa,but no causal association between alcohol intake and dairy intake and PCa onset.
关键词
孟德尔随机化法/前列腺癌/因果推断/全基因组关联研究/酒精/咖啡/绿茶/乳制品
Key words
Mendelian randomization/prostate cancer/causal inference/genome-wide association study/alcohol/coffee/green tea/dairy products
维普
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