Objective To explore the safety of transrectal ultrasound-guided transperineal injection of sodium hyaluronate to expand the Dirichlet gap in laparoscopic radical prostatectomy.Methods A total of 14 healthy male purebred beagle dogs were selected and randomly divided into 2 groups,with 7 in either group.The control group was treated with conventional laparoscopic radical prostatectomy,while the experimental group was treated with laparoscopic radical prostatectomy after 2.5 mL sodium hyaluronate was injected into the Dirichlet gap under the guidance of transrectal ultrasound.The total operation time,prostate separation time,intraoperative blood loss and rectal status of the 2 groups were observed.Results After the injection of sodium hyaluronate into the Dirichlet gap between the prostate and the rectum,no rectal tissue was found in the prostate,and no obvious damage was found in the posterior rectum in either groups.The postoperative hemoglobin(HGB)was[(118.70±2.56)g/L vs.(122.10±2.19)g/L,P=0.02];the total operation time was[(141.40±9.80)min vs.(119.10± 9.16)min,P＜0.05];the prostate separation time was[(24.99±1.75)min vs.(16.64±2.34)min,P＜0.05];the amount of bleeding was[(47.43±4.32)mL vs.(34.86±5.18)mL,P＜0.05]in the control group and experimental group.Conclusion Laparoscopic radical prostatectomy performed after 2.5 mL of sodium hyaluronate injection into the Dirichlet gap under the guidance of transrectal ultrasound can shorten the total operation time,the separation and resection time of the prostate,and reduce the amount of bleeding,which can improve and reduce the incidence of rectal injury,and prove the feasibility of this approach for prostatic cancer.
关键词
前列腺癌/直肠损伤/狄氏间隙/玻璃酸钠/腹腔镜/动物实验/根治性前列腺切除术/手术安全
Key words
prostate cancer/rectal injury/Dirichlet gap/sodium hyaluronate/laparoscope/animal experiment/radical prostatectomy/safety of surgery
维普
万方数据