现代泌尿外科杂志2024,Vol.29Issue(3) :284-289.DOI:10.3969/j.issn.1009-8291.2024.03.016

免疫治疗在前列腺癌中应用的现状及展望

Immunotherapy for prostate cancer:current status and future perspectives

方邦伟 朱耀
现代泌尿外科杂志2024,Vol.29Issue(3) :284-289.DOI:10.3969/j.issn.1009-8291.2024.03.016

免疫治疗在前列腺癌中应用的现状及展望

Immunotherapy for prostate cancer:current status and future perspectives

方邦伟 1朱耀1
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作者信息

  • 1. 复旦大学附属肿瘤医院泌尿外科,复旦大学上海医学院肿瘤学系,上海 200032
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摘要

免疫治疗作为一种新兴的癌症治疗方式,目前已经在多种实体肿瘤的治疗中表现出了良好的疗效,但在前列腺癌中该治疗方式未得到突破.本文旨在概述前列腺癌免疫治疗的应用现状,简述各种免疫治疗方法包括免疫检查点抑制剂、肿瘤疫苗及嵌合抗原受体T细胞(CAR-T)的原理和机制,总结临床试验的结果,并探讨免疫治疗在前列腺癌中所面临的挑战以及未来的应用展望.

Abstract

As an emerging cancer treatment modality,immunotherapy has shown promising efficacy in a variety of solid tumors,but it has failed to achieve a breakthrough in the treatment of prostate cancer.This review aims to provide an overview of the current applications of immunotherapy for prostate cancer,including immune-checkpoint inhibitors,cancer vaccines and chimeric antigen receptor T-cell(CAR-T),briefly describe the mechanisms of various immunotherapy modalities,summarize the results of clinical trials,and discuss the challenges and prospects.

关键词

前列腺癌/免疫治疗/肿瘤免疫微环境/免疫检查点抑制剂/肿瘤疫苗/嵌合抗原受体T细胞

Key words

prostate cancer/immunotherapy/tumor immune microenvironment/immune-checkpoint inhibitors/cancer vaccines/CAR-T

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出版年

2024
现代泌尿外科杂志
西安交通大学

现代泌尿外科杂志

CSTPCD
影响因子:1.106
ISSN:1009-8291
参考文献量61
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