Urosepsis caused by carbapenem-resistant gram-negative bacteria infection in patients with urinary calculi:case report and literature review of 6 cases
Objective To investigate the clinical characteristics and treatment strategies of urosepsis caused by carbapenem-resistant gram-negative bacteria(CRGNB)in patients with urinary calculi.Methods Clinical data of 6 urinary calculi patients with urosepsis due to CRGNB infection treated at our hospital were retrospectively analyzed.The clinical characteristics of infection and anti-infective drugs were analyzed according to the domestic and foreign guidelines and relevant literature.Results All 6 cases were nosocomial infection had a history of ureteral stent tube placement and invasive procedures,and 7 strains of CRGNB were detected with bacterial culture.All patients were improved after anti-infective treatment with single drug or multi-drug schemes.Among them,cases 3,4 and 6 were treated according to the minimum inhibitory concentration(MIC)value of drug sensitivity test,and had good outcomes.Conclusion Urosepsis caused by CRGNB infection in patients with urinary calculi is common in patients with positive bacterial culture and invasive procedures.Anti-infective therapy can flexibly adjust medication strategies according to the specific conditions of patients and changes in bacterial resistance to achieve the best therapeutic effects.
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