Objective To analyze the diagnostic value of prostate health index(PHI)plus soluble E-cadherin(sE-cadherin)for prostate cancer(PCa),so as to provide reference for the methods to enhance the detection rate of this disease.Methods A total of 200 patients with benign prostatic hyperplasia(BPH)admitted to our hospital during Jan.2018 and Jan.2023 were selected as the BPH group,and 200 PCa patients were enrolled as the PCa group.According to the different stages of the disease,the PCa patients were divided into stage Ⅰ-Ⅱ(n=92)and stage Ⅲ-Ⅳ(n=108)groups;according to the presence or absence of bone metastasis,they were divided into non-bone metastasis(n=146)and bone metastasis(n=54)groups;according to the Gleason score,they were divided into ≤8(n=111)and＞8(n=89)groups.Serum sE-cadherin was detected with ELISA kit.Total prostate specific antigen(tPSA),free prostate specific antigen(fPSA)and isoform[-2]prostate-specific antigen(p2PSA)were detected with chemiluminescence analyzer and PHI was calculated according to the formula.The diagnostic value of sE-cadherin combined with PHI for PCa was analyzed using receiver operating characteristic(ROC)curve analysis.Results Compared with the BPH group,the PCa group had elevated levels of sE-cadherin,tPSA,p2PSA and PHI(P＜0.05).Compared with patients with stage Ⅰ-Ⅱ PCa,stage Ⅲ-Ⅳ patients had increased levels of sE-cadherin,tPSA,p2PSA and PHI(P＜0.05).PCa patients with bone metastasis had higher levels of sE-cadherin,tPSA,p2PSA and PHI than those without bone metastasis(P＜0.05).Patients with Gleason score＞8 had higher levels of sE-cadherin,tPSA,p2PSA and PHI than those with Gleason score ≤8(P＜0.05).The area under the ROC curve(AUC)of sE-cadherin,PHI alone,and combined diagnosis were 0.719,0.761,and 0.792,respectively,the combined diagnosis had the highest AUC.Conclusion The levels of sE-cadherin and PHI are higher in PCa patients than in BPH patients,which increase with the increase of stage,bone metastasis and Gleason score.PHI plus sE-cadherin testing may help for the diagnose of PCa.
prostate cancersoluble E-cadherinprostate health indexprostate-specific antigenbone metastasis
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