现代泌尿外科杂志2024，Vol.29Issue(9) ：781-784.DOI:10.3969/j.issn.1009-8291.2024.09.007

脑部静息态功能磁共振低频振幅法检测盆底膀胱过度活动症患者大脑各区功能及结果分析

Detection and analysis of brain function in patients with pelvic floor overactive bladder by resting state functional magnetic resonance imaging with amplitude of low-frequency fluctuation

卫中庆 李云鹏 李春龙 赵素敏 丁留成 张思聪 张庆兵 夏强
现代泌尿外科杂志2024，Vol.29Issue(9) ：781-784.DOI:10.3969/j.issn.1009-8291.2024.09.007
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脑部静息态功能磁共振低频振幅法检测盆底膀胱过度活动症患者大脑各区功能及结果分析

Detection and analysis of brain function in patients with pelvic floor overactive bladder by resting state functional magnetic resonance imaging with amplitude of low-frequency fluctuation

卫中庆 1李云鹏 2李春龙 2赵素敏 3丁留成 2张思聪 2张庆兵 4夏强5
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作者信息

  • 1. 南京医科大学第二附属医院盆底外科、泌尿外科,江苏南京 210000;苏州大学附属无锡九院泌尿外科,江苏无锡 214100
  • 2. 南京医科大学第二附属医院盆底外科、泌尿外科,江苏南京 210000
  • 3. 山东省东阿县人民医院影像科,山东聊城 252200
  • 4. 山东省东阿县人民医院泌尿外科,山东聊城 252200
  • 5. 苏州大学附属无锡九院泌尿外科,江苏无锡 214100
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摘要

目的 采用脑部静息态功能磁共振(rs-fMRI)低频振幅(ALFF)法检测膀胱过度活动症(OAB)患者脑部各功能区信号图像并对结果进行分析探讨.方法 选取2021年3月 2023年3月于3家参与医院就诊并确诊为OAB的患者为OAB组(n=14),收集同期与OAB组患者性别、年龄、受教育年限匹配的健康人群作为对照组(NC组,n=14).比较两组受试者的膀胱过度活动症状评分表(OABSS)问卷调查、生活质量评分(QoL)、抑郁自评量表(SDS)及焦虑自评量表(SAS)评分.受试者均进行rs-fMRI检测,采集血氧水平依赖磁共振信号图像,采用ALFF技术处理图像数据,对结果进行两样本t检验,获取差异脑区.结果 OAB 组和 NC 组的 OABSS[(8.07±0.37)分 vs.(1.21±0.18)分]、QoL[(4.85±0.21)分 vs.(0.64±0.13)分]、SAS[(60.14±1.40)分vs.(37.64±1.57)分]及 SDS[(52.50±1.29)分 vs.(36.14±0.34)分]评分比较,OAB 组高于 NC 组,差异有统计学意义(P＜0.05).ALFF处理后结果显示,两组受试者ALFF值有明显差异的脑区分别位于左侧补充运动区、左侧额叶内侧额上回及右侧中央前回(P＜0.000 1).结论 静息状态下大脑的自发活动与相互协调能力异常可能与OAB的相应临床症状有关,涉及的功能异常脑区有左侧补充运动区、左侧额叶内侧额上回及右侧中央前回.

Abstract

Objective The amplitude of low-frequency fluctuation(ALFF)resting state functional magnetic resonance imaging(rs-fMRI)was used to investigate the signals image in the brain functional areas of overactive bladder(OAB)patients.Methods OAB patients treated in 3 participating hospitals during Mar.2021 and Mar.2023 were selected as the OAB group(n=14).Healthy subjects matching the gender,age and years of education of the patients in the OAB group were collected as the control group(NC group,n=14).Changes in the over active bladder symptom score(OABSS),quality of life scale(QoL),self-rating depression scale(SDS),self-rating anxiety scale(SAS)were analyzed.All subjects underwent rs-fMRI to collect blood oxygen level dependent magnetic resonance signals,which were then processed with ALFF.Two-sample t-test was conducted on the results to obtain the different brain regions.Results The OABSS[(8.07±0.37)vs.(1.21±0.18)],QoL[(4.85±0.21)vs.(0.64±0.13)],SAS[(60.14±1.40)vs.(37.64±1.57)]and SDS[(52.50±1.29)vs.(36.14±0.34)]scores of the OAB group were higher than those of the NC group,with significant differences(P＜0.05).The brain regions with significant differences in ALFF were located in the left supplementary motor area,left medial superior frontal gyrus and right anterior central gyrus(P＜0.000 1).Conclusion The abnormal spontaneous activity and coordination ability of the brain in resting state may lead to OAB symptoms,which are displayed in the abnormal functions of the left supplementary motor area,left medial superior frontal gyrus and right anterior central gyrus.

关键词

静息态功能磁共振/膀胱过度活动症/低频振幅/脑部功能区

Key words

resting state functional magnetic resonance imaging/overactive bladder/amplitude of low-frequency fluctuation/brain functional areas

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基金项目

江苏省科技厅社发基金项目(BE2020724)

国家自然基金面上项目(82370781)

出版年

2024
现代泌尿外科杂志
西安交通大学

现代泌尿外科杂志

CSTPCD
影响因子：1.106
ISSN：1009-8291
参考文献量3
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