现代泌尿外科杂志2024，Vol.29Issue(9) ：815-818.DOI:10.3969/j.issn.1009-8291.2024.09.013

基于倾向性评分匹配对比瑞马唑仑与丙泊酚对无痛前列腺穿刺患者术后恶心呕吐的影响

Comparison of the effects of remimazolam and propofol on postoperative nausea and vomiting in patients undergoing painless prostate biopsy based on propensity score matching

杜海亮 梁亮 李岩松 罗大伟 张香 宋平义 朱耀民
现代泌尿外科杂志2024，Vol.29Issue(9) ：815-818.DOI:10.3969/j.issn.1009-8291.2024.09.013
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基于倾向性评分匹配对比瑞马唑仑与丙泊酚对无痛前列腺穿刺患者术后恶心呕吐的影响

Comparison of the effects of remimazolam and propofol on postoperative nausea and vomiting in patients undergoing painless prostate biopsy based on propensity score matching

杜海亮 1梁亮 2李岩松 1罗大伟 2张香 1宋平义 1朱耀民1
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作者信息

  • 1. 西安交通大学第一附属医院麻醉手术部,陕西西安 710061
  • 2. 西安交通大学第一附属医院泌尿外科,陕西西安 710061
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摘要

目的 探讨甲苯磺酸瑞马唑仑(简称瑞马唑仑)和丙泊酚对无痛前列腺穿刺患者术后恶心呕吐(PONV)的影响,以期优化前列腺穿刺患者的麻醉方案.方法 回顾性分析西安交通大学第一附属医院2023年1月—2024年6月接受无痛前列腺穿刺的1217例患者的临床资料,其中1 093例符合纳入标准,按照使用麻醉药物不同分为瑞马唑仑组(n=294),丙泊酚组(n=799).通过1∶1倾向性评分匹配控制组间混杂因素后,每组267例患者.比较倾向性评分匹配前后两组患者的基线资料,PONV发生率及麻醉苏醒时间.结果 倾向性评分匹配前,与丙泊酚组比较,瑞马唑仑组患者的年龄更大[63(49,78)岁vs.66(53,83)岁],身体质量指数(BMI)更大[24.46(20.79,28.91)vs.25.30(21.83,29.23)],术中舒芬太尼使用量更多[7(6,9)µg vs.9(8,10)μg],术中昂丹司琼使用率更高(47.6％vs.55.4％),手术时间更长[15(13,17)min vs.16(14,20)min],差异均有统计学意义(P＜0.05).倾向性评分匹配后,两组患者上述一般资料指标比较,差异均无统计学意义(P＞0.05).倾向性评分匹配前,瑞马唑仑组患者PONV发生率高于丙泊酚组(17.7％vs.11.5％,P=0.007);倾向性评分匹配后,瑞马唑仑组与丙泊酚组患者PONV发生率差异无统计学意义(12.7％vs.17.2％,P=0.146).倾向性评分匹配前后,瑞马唑仑组患者麻醉苏醒时间均短于丙泊酚组[3(2,4)min vs.7(4,10)min,P＜0.001].结论 与丙泊酚相比,瑞马唑仑并不增加无痛前列腺穿刺患者PONV发生率且能缩短麻醉苏醒时间.

Abstract

Objective To investigate the effects of remimazolam and propofol on postoperative nausea and vomiting(PONV)in patients undergoing painless prostate biopsy,so as to optimize the anesthesia protocols.Methods A retrospective analysis was conducted on the clinical data of 1217 patients who underwent painless prostate biopsy in our hospital during Jan.2023 and Jun.2024.Among them,1093 patients met the inclusion criteria and were divided into two groups:the remimazolam group(n=294)and the propofol group(n=799).After 1∶1 propensity score matching,with 267 patients in either group,a comparison was conducted regarding the incidence of PONV and anesthesia recovery time.Results Before propensity score matching,the remimazolam group had older age[66(53,83)years vs.63(49,78)years],higher body mass index(BMI)[25.30(21.83,29.23)vs.24.46(20.79,28.91)],larger intraoperative use of sufentanil[9(8,10)μg vs.7(6,9)μg],higher intraoperative use rate of ondansetron(55.4％vs.47.6％),and longer surgical duration[16(14,20)min vs.15(13,17)min],with statistically significant differences(P＜0.05).There were no statistically significant differences in the aforementioned factors between the two groups after propensity score matching(P＞0.05).Before propensity score matching,the incidence of PONV was higher in the remimazolam group than in the propofol group(17.7％vs.11.5％,P=0.007),while after propensity score matching,the incidence of PONV did not differ significantly between the two groups(12.7％vs.17.2％,P=0.146).Before and after propensity score matching,the anesthesia recovery time was significantly shorter in the remimazolam group than in the propofol group[3(2,4)min vs.7(4,10)min,P＜0.001].Conclusion Compared with propofol,remimazolam does not increase the incidence of PONV in patients undergoing painless prostate biopsy but can shorten anesthesia recovery time.

关键词

甲苯磺酸瑞马唑仑/丙泊酚/前列腺穿刺/术后恶心呕吐

Key words

remimazolam/propofol/prostate biopsy/postoperative nausea and vomiting

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出版年

2024
现代泌尿外科杂志
西安交通大学

现代泌尿外科杂志

CSTPCD
影响因子：1.106
ISSN：1009-8291
参考文献量1
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