Objective To explore the causal relationship between the body mass index(BMI)and the risk of urinary tumors using two-sample Mendelian randomization.Methods BMI data in IEU public database genome association and date of kidney cancer,prostate cancer,prostate cancer,bladder cancer were screened and analy through the inverse variance weighting method,MR-Egger regression analysis,weighted median analysis of two-sample mondel randomization method to evaluate the causal relationship between constitution index and urinary tumor.Finally,a sensitivity analysis was used to assess the stability and reliability of the results.Results Genetically-predicted BMI is positively related to the risk of kidney cancer(OR:1.4425,95％CI:l.082 1-1.923 0,P=0.012 5),negatively related to the risk of prostate cancer(OR:0.992 6,95％CI:0.988 7-0.996 5,P=0.000 2),and had no causal relationship with the risk of bladder cancer(OR:1.000 3,95％CI:0.999 4-1.001 1,P=0.526 9).Sensitivity analysis and pleiotropy analyses showed that the results of this study were reliable and there was no heterogeneity.Conclusion Genetically-predicted BMI is a risk factor for renal cancer and a protective factor for prostate cancer.It is not associated with the risk of bladder cancer.This finding can provide reference for the potential risk of common urological tumors and the development of prevention strategies.
关键词
孟德尔随机化/身体质量指数/泌尿系肿瘤/因果推断/全基因组关联研究/肾癌/前列腺癌/膀胱癌
Key words
Mendelian randomization/body mass index/urinary tumors/causal inference/genome-wide association study/renal cancer/prostate cancer/bladder cancer
维普
万方数据