Objective To summarize the clinical manifestations,pathological characteristics,treatment options and prognosis of the world's first case of prostate ductal adenocarcinoma(PDA)complicated with prostate mucinous adenocarcinoma(PMA).Methods The clinical and follow-up data of a patient with PDA and PMA treated in Zhongnan Hospital of Wuhan University were retrospectively analyzed,and relevant literature in PubMed and CNKI databases was retrieved.Results The patient sought medical attention due to dysuria,frequent urination,urinary urgency and urinary pain for more than half a year,and was admitted to hospital 3 times in total.The initial diagnosis upon the first admission was benign prostatic hyperplasia complicated with prostatic abscess.After 2 months,the patient was readmitted due to worsening symptoms,received transurethral bladder neck incision+cystoscopy+transurethral plasma resection of the prostate,and postoperative diagnosis confirmed PDA with local PMA.Three months after surgery,the patient had bleeding.After auxiliary examinations revealed extensive metastasis,he received hormonal therapy.After 9 months,the patient died due to multiple lung metastases.Conclusion Early diagnosis has a significant impact on the treatment and prognosis,but there have been no previous reports of PDA combined with PMA,so the lack of specific biomarkers in the early stage has led to missed diagnosis or misdiagnoses.There is no specific treatment for PDA with PMA.Radical prostatectomy was not satisfactory in the treatment of this case.
关键词
前列腺癌/导管腺癌/黏液腺癌/前列腺特异性抗原
Key words
prostate cancer/prostate ductal adenocarcinoma/prostate mucinous adenocarcinoma/prostate special antigen
维普
万方数据