Objective To summarize the diagnosis and treatment of Antopol Goldman lesion(AGL)in clinical practice.Methods Clinical data and diagnosis and treatment process of one AGL case treated in our hospital were retrospectively analyzed,and relevant literature was reviewed.Results The patient presented with painless gross hematuria and right-sided lower back pain.Imaging examination suggested swelling of the right kidney,blood accumulation in the right calyx,renal pelvis and lower ureter,blood clot in the bladder,and multiple small stones in the left kidney.After multidisciplinary consultation,close imaging follow-up,interventional and flexible ureterdscope examination,tumors of hematological diseases,renal hematuria,arteriovenous fistula and collection system were excluded.After conservative treatment,the patient gradually recovered.During the follow-up of 1 year.no hematuria or low back pain recurred.Conclusion There is no clear diagnostic standard for AGL.Diagnosis relies on imaging,interventional methods and ureteroscopy.It is necessary to exclude other diseases and adopt conservative treatment.