首页|输尿管远端结石药物排石治疗研究进展

输尿管远端结石药物排石治疗研究进展

Research progress in the treatment of distal ureteral calculi with drugs

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输尿管结石梗阻引发的肾绞痛是尿路结石患者急诊就诊的主要原因,药物排石疗法在治疗中发挥着重要的作用.本文深入探讨了多种药物,包括α1肾上腺素能受体阻断药、β肾上腺素能受体激动剂、钙通道阻滞剂、前列腺素合成酶抑制剂、皮质类固醇、磷酸二酯酶同工酶5抑制剂以及中草药等在治疗输尿管远端结石中的作用机制和应用情况.目前,α1肾上腺素能受体阻断药因其疗效显著仍被视为治疗输尿管远端结石的首选药物.值得注意的是,各种药物能通过不同机制发挥作用,因此联合使用不同机制的药物有望提升排石效率,联合用药法可能成为未来药物排石治疗的主流选择.本文旨在为尿路结石的药物治疗提供新的视角和思路.
Renal colic caused by ureteral stone obstruction is the main cause for emergency treatment of patients with urinary tract stones,and drug expulsion therapy plays a vital role in the treatment.This article delves into a variety of drugs,including α1 adrenergic receptor blockers,β adrenergic receptor agonists,calcium channel blockers,prostaglandin synthetase inhibitors,corticosteroids,phosphodiesterase isoenzyme 5 inhibitors,and Chinese herbal medicines,exploring their mechanisms and applications in the treatment of distal ureteral stones.Currently,α1 adrenergic receptor blockers are still preferred for the treatment of distal ureteral stones due to their significant efficacy.It is worth noting that various drugs work through different mechanisms,and combining drugs with different mechanisms is expected to improve the efficiency of stone expulsion.This method may become the mainstream choice for stone expulsion drugs in the future.This article aims to provide new perspectives and ideas for the drug treatment of urinary tract stones.

distal ureteral calculimedical expulsive therapyα1 adrenergic receptor blockerβ adrenergic receptor agonistscalcium channel blockersprostaglandin synthetase inhibitorscorticosteroidsphosphodiesterase isoenzyme 5 inhibitors

李周鑫、张磊、程跃、谢国海

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宁波大学医学院,浙江宁波 315000

宁波市泌尿系疾病临床医学研究中心,浙江宁波 315500

泌尿系疾病创新技术与诊疗器械,浙江省工程中心,浙江宁波 315500

宁波大学附属第一医院泌尿外科,浙江宁波 315500

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输尿管远端结石 药物排石 α1肾上腺素能受体阻断药 β肾上腺素能受体激动剂 钙通道阻滞剂 前列腺素合成酶抑制剂 皮质类固醇 磷酸二酯酶同工酶5抑制剂

2024

10.3969/j.issn.1009-8291.2024.12.018

现代泌尿外科杂志
西安交通大学

现代泌尿外科杂志

CSTPCD
影响因子：1.106
ISSN：1009-8291
年,卷(期)：2024.29(12)