Atherosclerosis,a chronic inflammatory disease of the arterial wall,serves as the pathophysiological basis for ischemic stroke and coronary heart disease,and stands as the primary cause of cardiovascular and cerebrovascular comorbidity.Both the heart and brain share similar risk factors,including hypertension,hyperlipidemia and diabetes,and so on.Furthermore,most patients with cardiovascular and cerebrovascular comorbidity experience more severe disease and poorer prognosis.This article comprehensively reviews research progress in the pathophysiology of cardiovascular and cerebrovascular comorbidity,their related risk factors,and proposes the strategies of"synchronous treatment for brain and heart"to offer new insights for the prevention and management of cardiovascular and cerebrovascular comorbidity.
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