Central α-synucleinopathy includes Parkinson's disease(PD),dementia with Lewy bodies(DLB)and multiple system atrophy(MSA).The clinical manifestations of these diseases usually overlap,which make the differential diagnosis difficult in clinical practice.Autonomic dysfunction is a common feature of these diseases.Recent studies indicated the autonomic dysfunction would contribute to our further understanding of central α-synucleinopathy.This article reviews the value of autonomic dysfunction in the predictive diagnosis,differential diagnosis and prognosis of the above diseases,to help clinical practice.
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