Objective To analyze relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease(PD).Methods A total of 130 elderly patients with PD admitted to The Affiliated Brain Hospital of Nanjing Medical University from January 2020 to December 2022 were included.Hoehn-Yahr staging was used to evaluate stage of the disease,Unified Parkinson's Disease Rating Scale Ⅲ(UPDRS Ⅲ)was used to evaluate the severity of motor disorders,Scales for Outcomes in Parkinson's Disease-Autonomic(SCOPA-AUT)was used to evaluate autonomic nervous function,Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)were used to evaluate cognitive function,Non-Motor Symptoms Scale(NMSS)was used to evaluate the severity of non-motor symptoms.Results According to whether the patients were accompanied by Alzheimer's disease(AD),they were divided into a group with AD(n=82)and a group without AD(n=48).The proportion of Hoehn-Yahr staging 3 to 5(x2=5.689,P=0.017),UPDRS Ⅲ score(t=21.490,P=0.000),SCOPA-AUT score(t=21.330,P=0.000),dysregulation of body temperature(x2=8.512,P=0.004),urinary dysfunction(x2=17.270,P=0.000),gastrointestinal dysfunction(x2=24.471,P=0.000),dysregulation of pupil(x2=5.299,P=0.021),cardiovascular dysfunction(x2=15.355,P=0.000)and NMSS score(t=32.309,P=0.000)in the group with AD were higher than those in the group without AD,the MMSE(t=4.730,P=0.000)and MoCA(t=6.840,P= 0.000)total scores and subtype scores(P=0.000,for all)in the group with AD were lower than those in the group without AD.Correlation analysis showed that the SCOPA-AUT score of PD patients with AD was negatively correlated with MMSE and MoCA total scores and subtype scores(P=0.000,for all).Conclusions The autonomic dysfunction of elderly PD patients with AD is more serious,and the autonomic nervous function is closely related to cognitive function.
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