Analysis of factors influencing the severity of acute phase and short-term prognosis of anti-N-methyl-D-aspartate receptor encephalitis
Objective To explore the factors influencing the severity of acute phase and short-term prognosis of anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis,and search for potential indicators for assessing disease severity and predicting prognosis.Methods A total of 60 patients with anti-NMDAR encephalitis admitted to West China Hospital,Sichuan University from January 2020 to July 2023 were included.According to the modified Rankin Scale(mRS)during the acute phase,they were divided into mild group(mRS≤3 score,n=25)and severe group(mRS＞3 score,n=35),as well as good outcome group(mRS ≤ 3 score,n=32)and poor outcome group(mRS＞3 score,n=28)based on the mRS score after one month of treatment at our hospital.Univariate and multivariate Logistic regression analyses were used to determine the risk factors of anti-NMDAR encephalitis with severe condition during the acute phase and poor short-term prognosis.Results Logistic regression analysis showed consciousness disorder(OR=8.975,95％CI:2.048-39.327;P=0.004)and high level of neutrophil percentage-to-albumin ratio(NPAR;OR=5.004,95％CI:1.138-22.011,P=0.033)were the risk factors of anti-NMDAR encephalitis with severe condition during the acute phase,while high level of serum IgE was the protective factor(OR=0.994,95％CI:0.989-0.999;P=0.026).Female(OR=4.380,95％CI:1.205-15.929;P=0.025),consciousness disorder(OR=5.493,95％CI:1.535-19.657;P=0.009)and high level of NPAR(OR=2.949,95％CI:1.010-8.612;P=0.048)were the risk factors of anti-NMDAR encephalitis with poor short-term prognosis.Conclusions Consciousness disorder,low serum IgE level and high NPAR are risk factors of anti-NMDAR encephalitis with severe condition during the acute phase,while female,consciousness disorder and high NPAR are risk factors of anti-NMDAR encephalitis with poor short-term prognosis.NPAR is a potential biological indicator for assessing disease severity during the acute phase and predicting short-term prognosis of patients with anti-NMDAR encephalitis.
Anti N-methyl-D-aspartate receptor encephalitisHealth status indicatorsPrognosisRisk factorsLogistic models
万方数据
维普
