Glioma is often recurred after standard treatment due to its complex biological characteristics and the presence of glioma stem cells(GSCs).High-mobility group box 1(HMGB1)can regulate the malignant progression of glioma through a variety of ways as an oncogene.This article reviews the relationship between HMGB1 gene and the prognosis of glioma patients,tumor pathological grading,GSCs,and the ways including non coding RNA pathway,autophagy pathway,tumor microenvironment,etc.,in which HMGB1 gene regulates glioma,so as to provide the reference for the treatment of glioma.
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