Parkinson's disease(PD)is a common neurodegenerative disease in clinical practice.Patients with PD are usually accompanied by non-motor symptoms(NMS)such as gastrointestinal dysfunction,hyposmia,sleep disorders,depression,pain and hallucinations,which seriously reduce the quality of life.Recent studies have found that PD patients were accompanied by diffuse pathological changes in non-dopaminergic system such as progressive degeneration of 5-hydroxy tryptamine(5-HT)ergic neurons,and 5-HT plays an important role in the regulation of emotion,cognitive function,pain and other neural functions,and is closely related to non-motor symptoms of PD.This article reviews the correlation between 5-HT and non-motor symptoms of PD and its research progress,in order to further clarify the pathogenesis of non-motor symptoms of PD and provide a theoretical basis for the treatment of PD.
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