Effect of anti-inflammatory diet combined with fecal transplantation on the diversity and tolerance of intestinal flora in patients with ulcerative colitis
Objective To explore the effect of anti-inflammatory diet combined with fecal transplantation on the diversity and tolerance of intestinal flora in patients with ulcerative colitis(UC).Methods 150 UC patients in our hospital from March 2022 to April 2023 were included as the research object,and the patients were randomly divided into diet group,transplantation group and combined group,with 50 cases in each group.The diet group was given anti-inflammatory diet intervention,the transplantation group was given fecal transplantation treatment,and the combined group was given anti-inflammatory diet combined with fecal transplantation intervention.After 8 weeks,the remission of UC and the diversity of intestinal flora in the three groups were compared,and the tolerance of fecal transplantation in the transplantation group and the combined group was compared.Results The clinical remission rate and endoscopic remission rate in the combined group were 40.0％and 32.0％,which were significantly higher than those in the diet group and the transplantation group(P＜0.05),but there was no significant difference in the mucosal healing rate among the three groups(P＞0.05).After treatment,the ace,chao and shannon indexes of the combined group were higher than those of the diet group and the transplantation group(P＜0.05),and the transplantation group was higher than that of the diet group(P＜0.05).The incidence of fever and loss of appetite caused by adverse tolerance reaction of fecal transplantation in the combined group was lower than that in the transplantation group and the abdominal pain combined group with high transplantation group,but the difference was not statistically significant(P＞0.05).Conclusion The combination of anti-inflammatory diet and fecal transplantation can effectively promote the clinical and endoscopic remission of UC patients,improve the diversity of intestinal flora,and do not increase the intolerance of fecal transplantation.
万方数据
维普
