The relationship between gastric juice pH,EGF and PGE2 levels with the effectiveness of endoscopic treatment and gastrointestinal function in patients with gastric ulcer bleeding
Objective To explore the relationship between relationship between gastric juice pH,epidermal growth factor(EGF)and prostaglandin E2(PGE2)levels with the effectiveness of endoscopic treatment and gastrointestinal function in patients with gastric ulcer bleeding.Methods 67 patients with gastric ulcer bleeding who underwent digestive endoscopy treatment at Zhongnan Hospital of Wuhan University from January 2022 to May 2024 were selected.The levels of pH,EGF and PGE2 in gastric juice collected during endoscopic treatment of patients were detected.The effectiveness of disease treatment for patients was evaluated.The levels of gastric juice pH,EGF and PGE2 in patients with different therapeutic effects were copared,and the area under the ROC curve was used in the evaluation of gastric juice pH,EGF and PGE2 levels in early evaluation of treatment efficacy of digestive endoscopy treatment.The postoperative gastrointestinal function and recovery indicators such as bowel sound recovery time,anal exhaust time,hemostasis time,hospital stay time,and ulcer healing time for patients were selected,and the relationship between postoperative gastrointestinal function and recovery indicators with the levels of gastric juice pH,EGF and PGE2 were analyzed by Pearson correlation method and.Results The clinical treatment effectiveness rate of 67 patients with gastric ulcer bleeding was 71.64％(48/67).Compared with those of patients with effective treatment result,patients with ineffective treatment result had lower levels of gastric juice pH,EGF and PGE2(P＜0.05).The ROC curve analysis results showed that the levels of gastric juice pH,EGF and PGE2 have certain predictive value for the effectiveness of digestive endoscopy treatment,and the combined detection of the three had the best early evaluation efficacy.The postoperative recovery time of bowel sounds,anal exhaust time,hemostasis time,hospital stay time,and ulcer healing time of patients were(7.16±2.38)minutes,(26.96±6.41)hours,(20.66±4.37)hours,(4.52±1.16)days,and(23.14±4.18)days,respectively.The Pearson correlation analysis results showed that the levels of pH,EGF and PGE2 in gastric juice of patients with gastric ulcer bleeding were negatively correlated with postoperative gastrointestinal function and recovery indicators such as bowel sound recovery time,anal exhaust time,hemostasis time,hospital stay time,and ulcer healing time(P＜0.05).Conclusion The levels of gastric juice pH,EGF and PGE2 in patients with gastric ulcer bleeding are correlated with the effectiveness of endoscopic treatment,postoperative gastrointestinal function,and recovery time.They can be used as early evaluation reference indicators for the efficacy of endoscopic treatment of gastric ulcer bleeding patients.
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