Comparison of the effects of different probiotic preparations on serum TMAO,coagulation function,and intestinal mucosal barrier function in patients with ulcerative colitis
Objective To explore the differences in the effects of different probiotic preparations on serum trimethylamine oxide(TMAO),coagulation function,and intestinal mucosal barrier function in patients with ulcerative colitis,in order to provide reference for the application and selection of probiotic preparations in the treatment of ulcerative colitis.Methods 120 patients with active,mild to moderate ulcerative colitis admitted Into the General Hospital of the Southern Theater Command of the People's Liberation Army of China from January 2023 to February 2024 were selected and randomly divided into group A(n=30),Group B(n=30),Group C(n=30)and Group D(n=30)by random number table method.All four groups were treated with oral administration of mesalazine enteric coated tablets(1 g/time,3 times/day).In addition,Group A,Group B and Group C were treated with different probiotic preparations such as Peifeikang(0.42 g/time,2 times/day),Jinshuangqi(2 g/time,2 times/day),and Meichangan(0.5 g/time,3 times/day).All four groups were continuously treated and observed for 2 months.After treatment,modified Mayo score and modified Baron endoscopic score of the four groups were evaluated and compared,the treatment efficacy of the four groups were evaluated and the incidence of adverse reactions among the four groups was statistically compared.The before and after treatment coagulation function indicators(prothrombin time(PT),activated partial thromboplastin time(APTT),plasma fibrinogen(Fig)),serum TMAO,inflammatory factors(C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6))and intestinal mucosal barrier function(diamine oxidase(DAO),D-lactate and lipopolysaccharide(LPS))levels among the four groups were compared.Results Compared with the other three groups,the treatment effective rate of in Group D was lower,while the modified Mayo score and modified Baron endoscopic score after treatment in Group D were higher(P＜0.05);The treatment effective rate in Group C was lower than those of Group A and Group B,while the modified Mayo score and modified Baron endoscopic score after treatment in Group C were higher than those in Group A and Group B(P＜0.05);The after treatment modified Mayo score and modified Baron endoscopic score in Group B were higher than those in Group A(P＜0.05);However,there was no statistically significant difference in the treatment effectiveness between Group A and Group B(P＞0.05).Compared with those of before treatment in the same group,the after treatment PT and APTT in all four groups were shortened,while their plasma FIB levels and serum TMAO,IL-6,TNF-α,CRP,DAO,D-lactate,LPS levels were also all decreased(P＜0.05).Comparison results of after treatment APTT,PT,plasma FIB levels and serum TMAO,IL-6,TNF-α,CRP,DAO,D-lactate,LPS level of four groups showed that Group A＜Group B＜Group C＜Group D(P＜0.05).The incidence of adverse reactions in Group D were lower than that in Group A,Group B and Group C(P＜0.05);While there was no statistically significant difference among that of Group A,Group B and Group C(P＞0.05).Conclusion The application of probiotic preparations in patients with ulcerative colitis can help improve clinical treatment efficiency,improve clinical symptoms,coagulation function,inflammatory response,and intestinal mucosal barrier function,and reduce the occurrence of adverse reactions.Its application is safe and reliable,among which the application effect of multi probiotic preparations is better than that of single probiotic preparations,and the application effect of Peifeikang is the best.
Probiotic preparationsUlcerative colitisTrimethylamine oxide(TMAO)Coagulation functionIntestinal mucosal barrier function
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维普
